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Coaxial electrospinning is a novel technique for producing core-shell nanofibers that provide a robust structure and deliver hydrophilic bioactive agents. Optimization of parameters used in the coaxial electrospinning process allows for the fabrication of uniform and bead-free polyvinyl alcohol (PVA)/poly (l-lactic acid) (PLLA) core-shell nanofibers. Herein, a cold atmospheric plasma (CAP) process was used to enhance the surface features of electrospun core-shell nanofibers for increased surface pore size and altered surface hydrophilicity. After CAP treatment, the scaffolds' water contact angle was reduced from 110° to 50° and its protein and water adsorption were significantly elevated. The changes in hydrophilicity and improved scaffold surface area dramatically enhanced cell attachment and proliferation of fibroblasts and osteoblasts. Also, the increased levels of alkaline phosphatase (ALP) activity, total protein content and calcium deposition from mesenchymal stem cells (MSCs) indicated a higher osteoinductivity of the CAP-modified nanofibrous scaffold. Most importantly, the increased nanofiber surface pore size induced by the CAP treatment further contributed to significant variations in drug release profiles. The CAP-treated scaffolds showed more rapid release kinetics compared to untreated scaffolds, which eventually led to complete drug release. These results indicated that the CAP-treated and bioactive protein-loaded core-shell nanofibers could be a valuable regenerative medicine and drug delivery system for improved bone tissue engineering.
This article was published in the following journal.
Name: Biomaterials science
Nanoparticle-based drug delivery allows effective and sustained delivery of therapeutic agents to solid tumors and has completely changed how cancer is treated. As a new technology for medical applica...
To compare the influence of ultraviolet (UV) irradiation and cold atmospheric pressure plasma (CAP) treatment on surface structure, surface chemistry, cytocompatibility, and cell behavior on zirconia ...
To compare the efficacy of polyhexanide, cold argon plasma and saline in reducing bacterial bio-burden in dog bite wounds.
Yury Gorbanev is a Marie Curie postdoctoral research fellow at PLASMANT, University of Antwerp, working on analysis and development of biomedical cold plasma. He previously participated in an interdis...
The manufacture of a biocompatible carrier for controlled delivery of bioactive compounds is described. This carrier is composed of a mesoporous silica nanoparticle as core that is homogenously distri...
This study examines the efficacy of a non-thermal, atmospheric plasma device in the treatment of a number of different skin disorders
Cervical intraepithelial neoplasia will be treated with physical low temperature plasma in the plasma cohort compared to watchful waiting in the control cohort. Primary endpoint after 3-6...
This is single-center, prospective, randomized study
This clinical trial is being conducted to study the effect of whole hemp seed protein, hemp seed protein hydrolysate derived bioactive peptide and casein protein consumption on systolic an...
Clinical performance of bioactive restorative material versus Resin Modifeid Glass Ionoer (RMGI) in class V o will be evaluated over 12 months using United State Public Health Criteria (US...
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.
The atmospheric properties, characteristics and other atmospheric phenomena especially pertaining to WEATHER or CLIMATE.
Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.
A retinoblastoma-binding protein that is found as a subunit of protein complexes involved in the acetylation of newly synthesized histones. Although initially discovered as a retinoblastoma binding protein, it also has an affinity for core HISTONES and plays a role in recruiting core histone proteins to the active site of the acetyltransferase enzyme complexes.
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells. In vertebrates, it is composed of blo...
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...