Suppressive effect of everolimus on IL-2, IL-10, IL-21, and IFNγ levels: Implications for the successful minimization of calcineurin inhibitor use in transplantation.

08:00 EDT 29th March 2019 | BioPortfolio

Summary of "Suppressive effect of everolimus on IL-2, IL-10, IL-21, and IFNγ levels: Implications for the successful minimization of calcineurin inhibitor use in transplantation."

Success with calcineurin inhibitors (CNI) such as cyclosporine (CSA) and tacrolimus (TAC) in organ transplantation has demonstrated that cytokine suppression is a key factor in patient management. However, the exact effects of recently introduced immunosuppressive agents other than CNI on cytokine expression remain unknown. In the present study, the action of the mTOR-inhibitor everolimus (EVR) and that of the anti-metabolite mycophenolic acid (MPA) on the transcription of several cytokines was investigated.


Journal Details

This article was published in the following journal.

Name: Therapeutic drug monitoring
ISSN: 1536-3694


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Medical and Biotech [MESH] Definitions

A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Compounds that inhibit or block the PHOSPHATASE activity of CALCINEURIN.

A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT.

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