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The rising threat of vector-borne diseases and environmental pollution has instigated the investigation of nanotechnology-based applications. The current study deals with a nanotechnological application involving the usage of nanometric pesticides such as permethrin nanoemulsion. The mean droplet diameter and zeta potential of the prepared permethrin nanoemulsion were found to be 12.4 ± 1.13 nm and -20.4 ± 0.56 mV, respectively. The temporal stability of permethrin nanoemulsion was found to be 4 days when checked in the external environment. The permethrin nanoemulsion exhibited LC values of 0.038 and 0.047 mgL-1 and 0.049 and 0.063 mgL against larval and pupal stages of Culex tritaeniorhynchus and Aedes aegypti, respectively. The results obtained from the larvicidal and pupicidal assay were corroborated with the histopathological and biochemical profiles of hosts upon treatment with nanometric pesticide. Further, the biosafety studies of the nanopesticide were carried out against different non-target species like freshwater algae (Closterium), Cicer arietinum (Chickpea) and Danio rerio (Zebrafish), and the mosquitocidal concentration of nanopesticide was found to be non-toxic. The following study, therefore, describes the mosquitocidal efficacy of nanometric pesticide formulated in a greener approach, which can become a substitute for conventional pesticide application in an eco-benign manner.
This article was published in the following journal.
Name: Ecotoxicology and environmental safety
Self-dispersing lipid-based formulations, particularly self-microemulsifying drug delivery systems (SMEDDS) have gained an increased interest in recent times as a means to enhance the oral bioavailabi...
Evaluation of standard pyrethroid based LNs (MiraNet and MagNet) in experimental huts against pyrethroid resistant Anopheles gambiae s.l. M'bé, Côte d'Ivoire: Potential for impact on vectorial capacity.
There is evidence from experimental hut and household studies that the entomological efficacy of long lasting pyrethroid treated nets (LLINs) is compromised in areas of pyrethroid resistance. The rapi...
Whereas hydrophobic colloidal particles are known to destabilize foams and emulsions stabilized with surfactants, their use for destabilizing Pickering emulsions is unexplored. Pickering emulsions dif...
The current study documents enhanced apparent solubility of the BCS class II drug celecoxib (CXB) when formulated as solid phospholipid dispersion (SPD) with either mono- or diacyl-phospholipids by fr...
Polymer nanogels are used as colloidal stabilisers in emulsion polymerization. The nanogels were made by the covalent crosslinking of block copolymer micelles, the macromolecular building blocks of wh...
The purpose of this study is to evaluate the efficacy, limited pharmacokinetics (PK), and safety of 1,000 mg of Panzem® NCD administered orally four times a day to patients with recurrent...
The purpose of this trial is to evaluate the pharmacokinetics of single intravenous of Amphotericin B Colloidal Dispersion(ABCD)in Chinese healthy subjects.
This single-center, open-label, phase 2 study will evaluate the anti-tumor activity, as well as the safety and pharmacokinetics, of Panzem (2-methoxyestradiol, 2ME2) Nanocrystal Colloidal ...
The objective of this 1 week trial is to evaluate the efficacy of an over-the-counter (OTC) 1% colloidal oatmeal skin protectant cream in adults and children with mild to moderate AD.
Subjective and objective evaluation of the efficacy and tolerability of preservative-free "Ectoin® Eye Spray - Colloidal" and comparison of the efficacy and tolerability between "Ectoin®...
Medicated dosage forms for topical application in the vagina. A cream is a semisolid emulsion containing suspended or dissolved medication; a foam is a dispersion of a gas in a medicated liquid resulting in a light, frothy mass; a jelly is a colloidal semisolid mass of a water soluble medicated material, usually translucent.
The method of measuring the dispersion of an optically active molecule to determine the relative magnitude of right- or left-handed components and sometimes structural features of the molecule.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
Nanotechnology is the engineering of functional systems at the molecular scale. This covers both current work and concepts that are more advanced. In its original sense, 'nanotechnology' refers to the projected ability to construct items fr...
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity. This can be a drug or biochemical substance or a cell in an organism or organic sample. ...