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Modulation of cancer immunotherapy efficacy by gut microbiota.

07:00 EST 1st February 2019 | BioPortfolio

Summary of "Modulation of cancer immunotherapy efficacy by gut microbiota."

The microbial community is present abundantly in mucosal organs including the intestine, the oral cavity, and the vagina, and is referred to as the microbiota. The microbiota is composed of commensal bacteria and other microorganisms. Intestinal colonization by commensal microorganisms is essential for host physiological functions from the maintenance of barrier homeostasis locally to the regulation of metabolism, hematopoiesis, inflammation, immune development, and other functions systemically. Evidence is growing that the gut microbiota can modulate the host response to cancer immunotherapy. In this review, we discuss the evidence for the ability of the microbiota to modulate immunotherapy, their mechanisms of action, and the possibility of altering the microbiota to improve immunotherapy efficacy.

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Journal Details

This article was published in the following journal.

Name: Discovery medicine
ISSN: 1944-7930
Pages: 93-100

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Medical and Biotech [MESH] Definitions

Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)

Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient.

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Monocytes made cytotoxic by IN VITRO incubation with CYTOKINES, especially INTERFERON-GAMMA. The cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.

Loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one method in which some tumors escape detection by the immune system. Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies.

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