A pH-Sensitive Zwitterionic Iron Complex Probe with High Biocompatibility for Tumor-Specific MR Imaging.

08:00 EDT 2nd April 2019 | BioPortfolio

Summary of "A pH-Sensitive Zwitterionic Iron Complex Probe with High Biocompatibility for Tumor-Specific MR Imaging."

Accurate diagnosis of tumor characteristics, including its location and boundary, are of immense value to subsequent therapy. Activatable magnetic resonance imaging (MRI) contrast agents that respond to tumor-specific microenvironment, such as the redox state, pH, and enzyme activity, enable better mapping of tumor tissue. However, the practical application of most reported activatable agents is hampered by problems including potential toxicity, inefficient elimination, and slow activation. In this study, we developed a zwitterionic iron complex (Fe-ZDS) as a positive MRI contrast agent for tumor-specific imaging. Fe-ZDS could dissociate in weakly acidic solution rapidly, accompanied with obvious longitudinal relaxivity (r1) enhancement, which enabled the complex to act as a pH-sensitive contrast agent for tumor-specific MR imaging. In vivo experiments showed that Fe-ZDS rapidly enhanced the tumor-to-normal contrast ratio by > 40%, which assisted in distinguishing the tumor boundary. Furthermore, Fe-ZDS circulated freely in the bloodstream and was excreted relatively safely via kidneys owing to its zwitterionic nature. Therefore, Fe-ZDS is an ideal candidate for tumor-specific MRI contrast agent and holds considerable potential for clinical translation.


Journal Details

This article was published in the following journal.

Name: Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765


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