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Enantioselective Total Syntheses of (+)-Fendleridine and (+)-Acetylaspidoalbidine.

08:00 EDT 2nd April 2019 | BioPortfolio

Summary of "Enantioselective Total Syntheses of (+)-Fendleridine and (+)-Acetylaspidoalbidine."

Enantioselective syntheses of hexacyclic aspidoalbidine alkaloids (+)-fendleridine (2) and (+)-acetylaspidoalbidine (3) are described. These syntheses feature an asymmetric decarboxylative allylation and photocyclization of a highly substituted enaminone. Also, the synthesis highlights the formation of a C19-hemiaminal ether via a reduction/condensation/intramolecular cyclization cascade with the C21-alcohol. The present synthesis provides convenient access to the aspidoalbidine hexacyclic alkaloid family in an efficient manner.

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This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904
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