Cholinergic interneurons drive maladaptive changes in thalamostriatal circuitry after dopamine depletion.

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Summary of "Cholinergic interneurons drive maladaptive changes in thalamostriatal circuitry after dopamine depletion."

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Name: Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257


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Medical and Biotech [MESH] Definitions

INTERNEURONS with projections to the contralateral side of the SPINAL CORD. Both excitatory and inhibitory interneurons are involved in coordinating alternative left-right activities during LOCOMOTION.

Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.

Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)

Ipsilateral glycinergic inhibitory interneurons of the SPINAL CORD VENTRAL HORN which modulate recurrent firing of MOTOR NEURONS. They develop from embryonic progenitor domain V1.Ia inhibitory interneurons which also originate from V1 are responsible for reciprocal inhibition of MOTONEURONS.

Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.

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