Chemokine Receptor 7 is Essential for Coxiella burnetii Whole-Cell Vaccine Induced Cellular Immunity but Dispensable for Vaccine Mediated Protective Immunity.

08:00 EDT 2nd April 2019 | BioPortfolio

Summary of "Chemokine Receptor 7 is Essential for Coxiella burnetii Whole-Cell Vaccine Induced Cellular Immunity but Dispensable for Vaccine Mediated Protective Immunity."

Protective immunity against Coxiella burnetii infection is conferred by vaccination with virulent (PI-WCV), but not avirulent (PII-WCV) whole-cell inactivated bacterium. The only well characterized antigenic difference between virulent and avirulent C. burnetii is they have smooth and rough LPS respectively.


Journal Details

This article was published in the following journal.

Name: The Journal of infectious diseases
ISSN: 1537-6613


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Medical and Biotech [MESH] Definitions

Receptor for CHEMOKINE CX3CL1 expressed by lymphocytes, neurons, and GLIAL CELLS. Its interaction with CX3CL1 mediates CELL ADHESION and CELL MIGRATION. It also functions as a co-receptor with the CD4 ANTIGEN for HIV-1 in vitro.

An acute infectious disease caused by COXIELLA BURNETII. It is characterized by a sudden onset of FEVER; HEADACHE; malaise; and weakness. In humans, it is commonly contracted by inhalation of infected dusts derived from infected domestic animals (ANIMALS, DOMESTIC).

An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.

A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)

An INTEFERON-inducible CXC chemokine that is specific for the CXCR3 RECEPTOR.

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