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Another Warning for Febuxostat.

08:00 EDT 2nd April 2019 | BioPortfolio

Summary of "Another Warning for Febuxostat."

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Journal Details

This article was published in the following journal.

Name: JAMA
ISSN: 1538-3598
Pages: 1245

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PubMed Articles [220 Associated PubMed Articles listed on BioPortfolio]

The role of febuxostat in gout.

Concerns about the cardiovascular safety of febuxostat lead to reconsideration of the place of febuxostat in the management of gout.

Hypersensitivity and cardiovascular risks related to allopurinol and febuxostat therapy in Asians: A population-based cohort study and meta-analysis.

The safety of newer xanthine oxidase inhibitor-febuxostat comparing to allopurinol remains unclear. To compare the risks of allopurinol- and febuxostat-hypersensitivity and cardiovascular diseases (CV...

Protective effects of febuxostat against paraquat-induced lung toxicity in rats: Impact on RAGE/PI3K/Akt pathway and downstream inflammatory cascades.

The herbicide paraquat causes fatal lung toxicity by induction of xanthine oxidase, free radicals and inflammation. Febuxostat, a xanthine oxidase inhibitor and anti-gout has recently shown anti-infla...

Renal safety and urate-lowering efficacy of febuxostat in gout patients with stage 4-5 chronic kidney disease not yet on dialysis.

The safety and efficacy of febuxostat in patients with stage 4-5 chronic kidney disease (CKD) are still unclear owing to a lack of studies in these patients. Therefore, we aimed to evaluate the effect...

Effect of febuxostat on biochemical parameters of high fat diet-induced hyperlipidemia in rabbits.

Objective-To test the potential anti-oxidant and anti-inflammatory effects of febuxostat and/or stopping high-fat diet on the biochemical parameters of high fat diet-induced hyperlipidemic rabbits. Ba...

Clinical Trials [149 Associated Clinical Trials listed on BioPortfolio]

Phase 1, Febuxostat XR Bioavailability Study

This study will assess the bioavailability, safety and tolerability following administration of 80 mg single oral doses of 4 febuxostat extended release (XR) formulations.

Dose-Response, Safety and Efficacy of Febuxostat in Subjects With Gout

The purpose of this study is to determine the efficacy of febuxostat in reducing serum urate levels in subjects with gout.

Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemia

This is a randomized, double-blind, 3-period crossover phase 2 study in patients with documented hyperuricemia to evaluate the effect of tranilast on febuxostat pharmacokinetics (PK) and p...

RDEA3170 and Febuxostat Combination Study in Gout Subjects

This is a Phase 2a, randomized, open-label, multicenter study to assess the pharmacodynamic (PD) effects and safety of RDEA3170 administered in combination with febuxostat compared to febu...

Allopurinol Versus Febuxostat in Subjects Completing the Phase 3 Trials C02-009 or C02-010

The purpose of this study is to determine the long-term safety of febuxostat compared to allopurinol in reducing serum urate levels in subjects with gout.

Medical and Biotech [MESH] Definitions

A thiazole derivative and inhibitor of XANTHINE OXIDASE that is used for the treatment of HYPERURICEMIA in patients with chronic GOUT.

The family of omnivorous New World skunks, showing typical warning coloration of patterned black and white and able to eject a malodorous secretion when the animal is startled or in danger.

Organisms used to determine measurable environmental risks or hazards to human health and or well-being, thereby serving as advance or early warning signs of impending danger to humans. Examples of sentinel species are monkeys, guinea pigs, and the fabled canary in the coal mine.

Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.

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