Sulindac-derived RXRα modulator attenuates atherosclerotic plaque progression and destabilization in ApoE mice.

08:00 EDT 3rd April 2019 | BioPortfolio

Summary of "Sulindac-derived RXRα modulator attenuates atherosclerotic plaque progression and destabilization in ApoE mice."

Atherosclerosis is a chronic inflammatory disease, and retinoid X receptor alpha (RXRα) is an intriguing anti-atherosclerosis target. This study investigated whether and how an RXRα modulator, K-80003, derived from a non-steroidal anti-inflammatory drug (NSAID) attenuates atherosclerotic plaque progression and destabilization.


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This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381


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Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.

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