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Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels.

08:00 EDT 3rd April 2019 | BioPortfolio

Summary of "Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels."

At the present time, there is no successful synthetic, off-the-shelf small-caliber vascular graft (< 6 mm) for the repair or bypass of the coronary or carotid arteries. This stimulates on-going investigations to fabricate an artificial vascular graft that has both sufficient mechanical properties as well as superior biological performance. Collagen has long been considered as a viable material to encourage cell recruitment, tissue regeneration, and revascularization, but its use has been limited by its inferior mechanical properties. In this study, novel electrochemically aligned collagen (ELAC) filaments were used to engineer a bilayer small-caliber vascular graft, by circular knitting the collagen filaments and electrospinning collagen nanofibers. The collagen prototype grafts showed significantly greater bursting strength under dry and hydrated conditions to that of autografts such as the human internal mammary artery and the saphenous vein. The suture retention strength was sufficient under dry condition but that under hydrated condition needs to be further improved. The radial dynamic compliance of the collagen grafts was similar to that of the human saphenous vein. During in vitro cell culture assays with human umbilical vein endothelial cells, the prototype collagen grafts also encouraged cell adhesion and promoted cell proliferation compared to the synthetic poly (lactic acid) grafts. In conclusion, this study demonstrated the feasibility of the use of novel collagen filaments for fabricating small caliber tissue-engineered vascular grafts that provide both sufficient mechanical properties and superior biological performance.

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This article was published in the following journal.

Name: Biofabrication
ISSN: 1758-5090
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