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tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function.

08:00 EDT 31st March 2019 | BioPortfolio

Summary of "tRNAs and tRNA fragments as modulators of cardiac and skeletal muscle function."

Transfer RNAs (tRNAs) and their processing enzymes have long-recognized roles in cardiac and skeletal muscle pathophysiology. Recently, tRNA fragments have emerged as a new class of non-coding RNAs involved in the regulation of cell function. In this review, we provide a synopsis of the molecular processes that regulate the biogenesis, post-transcriptional regulation and functional roles of tRNAs in cardiac and skeletal muscle. In addition, we list the (dys)regulated expression profiles and putative functional roles of tRNA-derived small RNAs in the heart and skeletal muscle. Finally, the technical challenges surrounding tRNA research are discussed alongside suggestions to advance research in this field. This article is part of a Special Issue entitled: Cardiomyocyte biology: new pathways of differentiation and regeneration edited by Marijke Brinkm, Marcus C. Schaub, and Christian Zuppinger.

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This article was published in the following journal.

Name: Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
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