Synthesis of het(aryl) imidazole C-nucleoside analogues by CoFeO NPs catalyzed muti-component coupling reaction.

08:00 EDT 3rd April 2019 | BioPortfolio

Summary of "Synthesis of het(aryl) imidazole C-nucleoside analogues by CoFeO NPs catalyzed muti-component coupling reaction."

A general synthesis of hetaryl and aryl C-4(5) linked imidazole C-nucleoside analogues has been developed by the reaction of sugar alkynes with het(aryl) iodides, KMnO/TBAB oxidation and CoFeO NPs catalyzed muti-component coupling of the corresponding diketones, NHOAc and aromatic aldehydes in one-pot. The sugar alkynes include pyranosides and furanosides with acid sensitive protecting groups. The het(aryl) iodides comprise iodoaromatics, iodoheterocycles, and sterically hindered iodoheteroaromatics.


Journal Details

This article was published in the following journal.

Name: Carbohydrate research
ISSN: 1873-426X
Pages: 39-50


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Medical and Biotech [MESH] Definitions

A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV infection and AIDS.

An enzyme that catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside monophosphate, e.g., UMP, to form ADP and UDP. Many nucleoside monophosphates can act as acceptor while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC

A nucleoside diphosphate kinase subtype that is localized to the intermembrane space of MITOCHONDRIA. It is believed to play a role in the synthesis of triphosphonucleotides using ATP formed through OXIDATIVE PHOSPHORYLATION.

An enzyme that is found in mitochondria and in the soluble cytoplasm of cells. It catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleoside diphosphate, e.g., UDP, to form ADP and UTP. Many nucleoside diphosphates can act as acceptor, while many ribo- and deoxyribonucleoside triphosphates can act as donor. EC

An enzyme which catalyzes the hydrolysis of nucleoside triphosphates to nucleoside diphosphates. It may also catalyze the hydrolysis of nucleotide triphosphates, diphosphates, thiamine diphosphates and FAD. The nucleoside triphosphate phosphohydrolases I and II are subtypes of the enzyme which are found mostly in viruses.

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