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The expanding family of noncanonical regulatory cell subsets.

08:00 EDT 8th April 2019 | BioPortfolio

Summary of "The expanding family of noncanonical regulatory cell subsets."

The overwhelming body of research on regulatory lymphocytes has focused on CD4 CD25 Foxp3 T cells (regulatory T cells); however, the last 5 years have witnessed inspiring progress in our understanding of regulatory B cells, regulatory CD8 T cells, regulatory γδ cells, and, more recently, regulatory innate lymphoid cells(ILCregs). This review focuses on these so-called noncanonical regulatory cell subsets. We primarily survey existing information on the phenotype, function, sustaining factors, and clinical value of the 4 best-characterized non-CD4 Foxp3 T regulatory cells. We then take a brief journey into the advances and challenges associated with next-generation sequencing technologies and the application of sequencing to the study of noncanonical regulatory cell subsets.

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This article was published in the following journal.

Name: Journal of leukocyte biology
ISSN: 1938-3673
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