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TiO2 nanopillar arrays coated with gelatin film for efficient capture and undamaged release of circulating tumor cells.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "TiO2 nanopillar arrays coated with gelatin film for efficient capture and undamaged release of circulating tumor cells."

Circulating tumor cells (CTC) are important for the detection and treatment of cancer. Nevertheless, the badly low density of circulating tumor cells makes the capture and release of CTCs an obstacle. In this work, TiO2 nanopillar arrays coated with gelatin film was synthesized for efficient capture and undamaged release of circulating tumor cells. The SEM and AFM images demonstrate that the substrate has a certain roughness. And the interaction between the cell membrane and the nanostructure substrate contributes to the efficient capture of CTC (capture efficiency up to 94.98%). Besides, the gelatin layer has excellent biocompatibility and can be rapidly digested by matrix metalloproteinase (MMP9), which realize the non-destructive release of CTCs (0.1mg/mL, 5 min, nearly 100% release efficiency, activity 100%). Therefore, by our strategy, the CTCs can be efficiently captured and undamaged released, which is important for subsequent analysis.

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This article was published in the following journal.

Name: Nanotechnology
ISSN: 1361-6528
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