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Circulating tumor cells (CTC) are important for the detection and treatment of cancer. Nevertheless, the badly low density of circulating tumor cells makes the capture and release of CTCs an obstacle. In this work, TiO2 nanopillar arrays coated with gelatin film was synthesized for efficient capture and undamaged release of circulating tumor cells. The SEM and AFM images demonstrate that the substrate has a certain roughness. And the interaction between the cell membrane and the nanostructure substrate contributes to the efficient capture of CTC (capture efficiency up to 94.98%). Besides, the gelatin layer has excellent biocompatibility and can be rapidly digested by matrix metalloproteinase (MMP9), which realize the non-destructive release of CTCs (0.1mg/mL, 5 min, nearly 100% release efficiency, activity 100%). Therefore, by our strategy, the CTCs can be efficiently captured and undamaged released, which is important for subsequent analysis.
This article was published in the following journal.
After proper stimulation, long afterglow phosphors formulated as pigment in waterborne paints can emit light after the removal of the excitation light source. The encapsulation of SrAlO: Eu, Dy phosph...
In order to control foodborne pathogens on seafood products, an antimicrobial, thermoplastic starch/polybutylene adipate terephthalate (TPS/PBAT; 40/60) film was produced by coating gelatin (15% v/v) ...
In this paper, for the first time, polyaniline nanofibers/TiO2 nanotubes (PANI/TiO2) heterojunction thin film has been prepared on Pt interdigital electrodes by layer-by-layer self-assembly method and...
TiO2 has been widely used in ultraviolet (UV) photodetectors, but due to the large number of structural defects and strong band-to-band recombination of the exciton in TiO2, the devices usually have l...
In order to explore high performance and stable perovskite solar cells (PSCs), the design and optimization of electron transport layer (ETL) have been paid more and more attention. Vertically oriented...
Incidence of visual phenomena, heart rate at rest, safety (with particular emphasis on QT analysis of ECGs), and pharmacokinetic parameters
The present study was a randomized, open-label, two-period, two-sequence, cross-over study, conducted to find out whether the etoricoxib 120 mg film-coated tablet produced by PT Dexa Medic...
This was a randomized, single-blind, two-period, two sequence cross-over study under fasting condition, with a one-week wash-out period, to compare the pharmacokinetic profiles and bioavai...
The purpose of this study is to determine the bioequivalence of Rosuvastatin/ Verisfield 20 mg film-coated tablets and Crestor™/ AstraZeneca 20 mg film-coated tablets.
To establish bioequivalence between new film-coated tablet formulations of 0.5 mg, 1 mg and 5 mg flupentixol and the marketed coated tablet formulations of 0.5 mg, 1 mg, and 5 mg flupentix...
A film base coated with an emulsion designed for use with x-rays.
Use of a device (film badge) for measuring exposure of individuals to radiation. It is usually made of metal, plastic, or paper and loaded with one or more pieces of x-ray film.
The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.
Sterile, gelatin-base surgical sponge applied topically as an adjunct to hemostasis when the control of bleeding by conventional procedures is ineffective to reduce capillary ooze or is impractical. (From AMA Drug Evaluations Annual, 1994, p797)
Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. These pits are the entry route for macromolecules bound by cell surface receptors. The pits are then internalized into the cytoplasm to form the COATED VESICLES.
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...