Targeted breath analysis: exogenous volatile organic compounds (EVOC) as metabolic pathway-specific probes.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Targeted breath analysis: exogenous volatile organic compounds (EVOC) as metabolic pathway-specific probes."

Breath research has almost invariably focussed on the identification of endogenous volatile organic compounds (VOCs) as disease biomarkers. After five decades, a very limited number of breath tests measuring endogenous VOCs is applied to the clinic. In this perspective article, we explore some of the factors that may have contributed to the current lack of clinical applications of breath endogenous VOCs. We discuss potential pitfalls of experimental design, analytical challenges, as well as considerations regarding the biochemical pathways that may impinge on the application of endogenous VOCs as specific disease biomarkers. We point towards several lines of evidence showing that breath analysis based on administration of exogenous compounds has been a more successful strategy, with several tests currently applied to the clinic, compared to measurement of endogenous VOCs. Finally, we propose a novel approach, based on the use of exogenous VOC (EVOC) probes as potential strategy to measure the activity of metabolic enzymes in vivo, as well as the function of organs, through breath analysis. We present longitudinal data showing the potential of EVOC probe strategies in breath analysis. We also gathered important data showing that administration of EVOC probes induces significant changes compared to previous exposures to the same compounds. EVOC strategies could herald a new wave of substrate-based breath tests, potentially bridging the gap between research tools and clinical applications.


Journal Details

This article was published in the following journal.

Name: Journal of breath research
ISSN: 1752-7163


DeepDyve research library

PubMed Articles [21469 Associated PubMed Articles listed on BioPortfolio]

Exhaled Volatile Organic Compounds are Able to Discriminate between Neutrophilic and Eosinophilic Asthma.

Analysis of exhaled breath for asthma phenotyping using endogenously generated volatile organic compounds (VOCs) offers the possibility of noninvasive diagnosis and therapeutic monitoring. Induced spu...

Volatile Organic Compounds in Patients With Acute Kidney Injury and Changes During Dialysis.

To characterize volatile organic compounds in breath exhaled by ventilated care patients with acute kidney injury and changes over time during dialysis.

Beyond monoisotopic accurate mass spectrometry: ancillary techniques for identifying unknown features in non-targeted discovery analysis.

High-resolution mass spectrometry (HR-MS) is an important tool for performing non-targeted analysis for investigating complex organic mixtures in human or environmental media. This perspective demonst...

Ionic Liquid-Carbon Nanotube Sensor Arrays for Human Breath Related Volatile Organic Compounds.

High sensitivity, selectivity, and stability are key requirements for carbon nanotube (CNT)-based sensors to realize their full potential in applications ranging from chemical warfare agent detection ...

The potential of breath analysis to improve outcome for patients with lung cancer.

Lung cancer remains the most common cause of cancer related death in both the UK and USA. Development of diagnostic approaches that have the ability to detect lung cancer early are a research priority...

Clinical Trials [4337 Associated Clinical Trials listed on BioPortfolio]

Analysis of Volatile Organic Compounds in the Exhaled Air in Inflammatory Bowel Disease

The availability of noninvasive biomarkers for diagnosis and stratification of inflammatory bowel disease (IBD) courses is lacking. Thus, the aim of this study is to evaluated the accuracy...

Exploratory Study of Volatile Organic Compounds in Alveolar Breath

The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.

Breath Volatile Organic Compounds Patterns of Lung Transplant Patients With Chronic Lung Allograft Dysfunction

It's the aim of this study to clarify, whether the non-invasive assessment of breath can serve as a novel clinical tool to assist in the diagnosis of CLAD. If different stages of BOS can b...

Diagnostic Breath Analysis Study to Detect Sepsis

Analysis of exhaled breath samples using a high-speed gas chromatography medical device will identify Volatile Organic Compounds (VOC) that are specifically associated with SIRS and Sepsis...

Volatiles in Breath and Headspace Analysis - Diagnostic Markers

Detection of Volatile Organic Compounds (VOC) directly from tissue by headspace analysis (skin, surgery material, other tissue) and exhaled breath is feasible using affordable user-friendl...

Medical and Biotech [MESH] Definitions

Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.

Organic compounds containing the nitroso (-N=O) group attached to an organic moiety.

Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.

Whitish aromatic crystalline organic compounds made up of two conjoined BENZENE rings.

Inorganic derivatives of ammonia by substitution of one or more hydrogen atoms with chlorine atoms or organic compounds with the general formulas R2NCl and RNCl2 (where R is an organic group).

Quick Search


DeepDyve research library

Relevant Topic

Asthma COPD Cystic Fibrosis Pneumonia Pulmonary Medicine Respiratory Respiratory tract infections (RTIs) are any infection of the sinuses, throat, airways or lungs.  They're usually caused by viruses, but they can also ...

Searches Linking to this Article