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Investigation of etoxazole metabolites in citrus, soil and earthworms by ultra-performance liquid chromatography with time-of-flight mass spectrometry.

08:00 EDT 2nd April 2019 | BioPortfolio

Summary of "Investigation of etoxazole metabolites in citrus, soil and earthworms by ultra-performance liquid chromatography with time-of-flight mass spectrometry."

Etoxazole is a newly registered and widely used acaricide. However, its metabolites were not fully understood and might exhibit similar or even higher toxicity than parent compound. Therefore, in this study, the metabolites of etoxazole in citrus, soil and earthworms were firstly identified by an ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS). Four potential metabolites in citrus, 11 in soil, and 8 in earthworms were determined. These metabolites were then further structural elucidated based on the fragment pathways, and accurate mass measurement. The distributions of etoxazole and its main metabolites (M1, M2, M3, M4 and M5) which were identified as the dehydrogenation, hydrolysis, oxidation products of etoxazole (M0) were also monitored in citrus, soil and earthworms at different exposure periods. The 45 days exposure experiment showed that M0 gradually decreased in citrus and soil samples by 80% and 28% of the initial amounts, respectively. In earthworm samples, M0 accumulated in the bodies of the worms during 24 days exposure and then decreased with time. The dissipation rate of etoxazole were citrus > earthworms > soil. Concentrations of M1 and M3 in soil were found continuously increased with time during the experimental period. Moreover, the persistence of M1 in earthworm samples was also observed. Great attention should be paid to these two compounds due to their potential risks to both environmental and human health.

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Journal Details

This article was published in the following journal.

Name: Chemosphere
ISSN: 1879-1298
Pages: 782-790

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A plant genus of the family LAMIACEAE. The common names of beebalm or lemonbalm are also used for MELISSA. The common name of bergamot is also used for Citrus bergamia (CITRUS).

A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing.

A plant species of the genus CITRUS, family RUTACEAE that provides the familiar orange fruit which is also a source of orange oil.

A plant species of the genus CITRUS, family RUTACEAE that provides the familiar lime fruit. Its common name of lime is similar to the limetree (TILIA).

A plant species of the genus CITRUS, family RUTACEAE that provides the familiar grapefruit. There is evidence that grapefruit juice inhibits CYTOCHROME P-450 isoform 3A4, resulting in delayed metabolism and higher blood levels of a variety of drugs.

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