Engineering a naturally-derived adhesive and conductive cardiopatch.

08:00 EDT 21st March 2019 | BioPortfolio

Summary of "Engineering a naturally-derived adhesive and conductive cardiopatch."

Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered cardiac tissues in vitro, there are still several limitations associated with engineering biocompatible scaffolds with appropriate mechanical properties and electroconductivity for cardiac tissue regeneration. Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. These GelMA/Bio-IL adhesive patches were optimized to exhibit mechanical and conductive properties similar to the native myocardium. Furthermore, the engineered patches strongly adhered to murine myocardium due to the formation of ionic bonding between the Bio-IL and native tissue, eliminating the need for suturing. Co-cultures of primary cardiomyocytes and cardiac fibroblasts grown on GelMA/Bio-IL patches exhibited comparatively better contractile profiles compared to pristine GelMA controls, as demonstrated by over-expression of the gap junction protein connexin 43. These cardiopatches could be used to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function.


Journal Details

This article was published in the following journal.

Name: Biomaterials
ISSN: 1878-5905
Pages: 89-101


DeepDyve research library

PubMed Articles [8625 Associated PubMed Articles listed on BioPortfolio]

Conductive organohydrogels with ultra-stretchability, anti-freezing, self-healing and adhesive properties for motion detection and signal transmission.

Conductive hydrogels had demonstrated significant prospect in the field of wearable devices. However, it was a huge limitation for hydrogels due to freezing after the temperature falls below zero. Her...

Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-healing, Adhesiveness and 3D Printability for Human Motion Sensing.

Self-healing, adhesive conductive hydrogels are of great significance in wearable electronic devices, flexible printable electronics and tissue engineering scaffolds. However, to design the self-heali...

Tough, adhesive, self-healable and transparent ionically conductive zwitterionic nanocomposite hydrogels as skin strain sensors.

It is desired to create skin strain sensors composed of multifunctional conductive hydrogels with excellent toughness and adhesion properties to sustain cyclic loadings during use and facilitate the e...

Enhancing neural differentiation of induced pluripotent stem cells by conductive graphene/silk fibroin films.

Nerve regeneration and function recovery remain challenges for tissue engineering. The application of suitable scaffold in tissue engineering has been demonstrated to be able to enhance nerve regenera...

Porcine-Derived Biomaterials in Tissue Engineering and Reconstructive Surgery: Considerations and Alternatives in Muslim Patients.

During the last three decades, tissue engineering and reconstructive surgery have become standard therapeutic options in the world of medicine. Several biomaterials, either alone, or in combination wi...

Clinical Trials [2142 Associated Clinical Trials listed on BioPortfolio]

Use of ADHEAR, a Non-Implantable Bone Conduction Hearing System, in Children With Single Sided Deafness and/or Conductive Hearing Loss

A hearing loss affects the quality of life and the natural development of children. The new generation of hearing devices provides a huge number of options to them. These new hearing aids...

Audiological Benefit and Quality of Life With Two Bone Conduction Systems: ADHEAR vs. Contact Mini

Patients with conductive hearing loss fitting the inclusion criteria will be asked to participate in the study. All subjects will be randomized to wear either first the adhesive or the con...

Investigating the Adhesion of New Adhesive to the Skin

The adhesion of the new adhesive strips is investigated on healthy volunteers

Comparison of a New Patient Warming System Using Polymer Conductive Warming With Forced Air Warming During Surgery

Two patient warming systems will be compared with 40 patients each in a convective warming group (BairHugger, Arizant) and in a conductive warming group (HotDog, Augustine Biomedical). ...

Evaluation of the Effect of Output on New Adhesives

The study investigates the impanct real output has on the adhesion of a new adhesive

Medical and Biotech [MESH] Definitions

Hearing loss due to damage or impairment of both the conductive elements (HEARING LOSS, CONDUCTIVE) and the sensorineural elements (HEARING LOSS, SENSORINEURAL) of the ear.

Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.

A rare PARAGANGLIOMA involving the GLOMUS TYMPANICUM, a collection of chemoreceptor tissue adjacent to the TYMPANIC CAVITY. It can cause TINNITUS and conductive hearing loss (HEARING LOSS, CONDUCTIVE).

Application of principles and practices of engineering science to the transformation, design, and manufacture of substances on an industrial scale.

A branch of engineering concerned with the design, construction, and maintenance of environmental facilities conducive to public health, such as water supply and waste disposal.

Quick Search


DeepDyve research library

Relevant Topic

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Searches Linking to this Article