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Non-invasive quantification of the in vivo myelin content may provide valuable information regarding healthy maturation of the brain, as well as insights into demyelination of several neurological disorders. However, these scans are often long thereby limiting acquisition of large brain parts in clinically feasible acquisition times. Therefore, fast acquisition of whole brain myelin content is important. To avoid errors related to slice-selective pulses, most of the previous whole brain studies on myelin content relied on a 3D acquisition. However, multi-slice (2D) acquisition methods are often faster, and less susceptible to motion artifacts. Therefore, multi-slice approaches can be beneficial in a clinical setting. We investigated the applicability and reproducibility of whole brain multi-slice GRASE myelin-water imaging with post-acquisition slice-profile correction in healthy volunteers (aged 25-32y). The applicability was evaluated using the agreement between the multi-slice GRASE and the reference method for myelin-water imaging, single-slice multi spin-echo (MSE) acquisition. Additionally, we assessed the effect of varying acquisition acceleration using parallel imaging on the reproducibility values. First, the multi-slice myelin-water maps showed good agreement with the single-slice reference method, with a bias of at most 1.2% in absolute MWF values. Second, we found an average within-subject coefficient of variation (CoV) of 5.9% and an average intra-class correlation coefficient (ICC) of 0.90 for myelin-water estimation using a multi-slice GRASE sequence without parallel acceleration (scan time 14:06 min), while acquisition with a parallel acceleration factor of 2 resulted in a slightly worse average within-subject CoV of 6.4% and an average ICC of 0.83 at half the scan time. Hence, a multi-slice GRASE acquisition with parallel acceleration factor 2 and a scan time of 7:30 min still provides an excellent reproducibility.
This article was published in the following journal.
Gradient echo myelin water imaging (GRE-MWI) is an MRI technique to measure myelin concentration and involves the analysis of signal decay characteristics of the multi-echo gradient echo data. The met...
Prenatal alcohol exposure (PAE) is linked to alterations of cerebral white matter, including volume and non-specific diffusion magnetic resonance imaging (MRI) indices of micro-structure in humans. So...
The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile...
Myelination of axons in the central nervous system is critical for human cognition and behavior. The predominant protein in myelin is proteolipid protein-making PLP1, the gene that encodes for proteol...
To develop a novel, simultaneous multi-slice (SMS) reconstruction that extends an inter-slice leakage constraint to intra-slice aliasing with a virtual slice concept for artifact reduction.
The purpose of this study is to evaluate the efficacy and safety of ONO-1101 in patients scheduled for multi-slice CT.
The purpose of the study is to compare Multi-Slice Computer Tomography findings with histological and physiological changes observed in transplanted lungs with Progressive Graft Disfunctio...
To detect and evaluate the predictors of graft patency after coronary artery bypass graft surgery as assessed by multi-slice CT coronary angiography validated by coronary angiography
The purpose of this study is to evaluate the reproducibility of tonometry in the Goldmann applanation apparatus and pneumatic in the water drinking test.
This study aims to prospectively assess the repeatability and reproducibility of iron-corrected T1 (cT1), T2*, and hepatic proton density fat fraction (PDFF) quantification with multiparam...
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Proteins found in the myelin sheath. The major proteins of central nervous system myelin include: MYELIN PROTEOLIPID PROTEIN; MYELIN BASIC PROTEINS; and MYELIN-ASSOCIATED GLYCOPROTEIN. The major proteins of peripheral nervous system myelin include: MYELIN BASIC PROTEINS (myelin P1 protein and MYELIN P2 PROTEIN); MYELIN P0 PROTEIN; and MYELIN-ASSOCIATED GLYCOPROTEIN.
A glycosylated extracellular myelin protein found on the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is linked to the cell surface via a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE.
A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It has a structure that is similar to members of the Ig superfamily that participate in cell adhesion. (From Siegel et al., Basic Neurochemistry, 5th ed, p132)
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
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