Natural history of dry eye disease: Perspectives from inter-ethnic comparison studies.

08:00 EDT 6th April 2019 | BioPortfolio

Summary of "Natural history of dry eye disease: Perspectives from inter-ethnic comparison studies."

Asian ethnicity is a mostly consistent dry eye disease (DED) risk factor. Co-located ethnic population studies, reducing potential confounding effects of methodological and environmental heterogeneity, may help explain DED natural history. From 96 references identified through the systematic literature search strategy of the current review, 3 relevant studies possessed sufficient methodological homogeneity for pooled analysis. Results show earliest disparities detected between Asian and Caucasian populations being higher degrees of incomplete blinking and lid wiper epitheliopathy in pediatric Asian participants, likely associated with anatomically predisposed increased eyelid tension. Interethnic divergence in meibomian gland dropout in the young adult population follows, while other ocular surface characteristics remain within physiological limits; significant differences in meibomian gland function, tear film stability and osmolarity, DED symptomology and overall disease diagnosis (based on TFOS DEWS II criteria) do not manifest until the middle adult population; and disparities in corneal and conjunctival staining become significant only with older age. Aqueous tear deficiency appears less likely than evaporative mechanisms to be implicated in the Asian ethnic propensity towards DED development. Two retrospective studies identified in the systematic literature search, further indicate susceptibility of the Asian population to iatrogenic DED secondary to contact lens wear and refractive surgery. Overall, the observation of increasing interethnic ocular surface differences throughout life has potential to offer valuable insight into the natural history of dry eye disease development.


Journal Details

This article was published in the following journal.

Name: The ocular surface
ISSN: 1937-5913


DeepDyve research library

PubMed Articles [25971 Associated PubMed Articles listed on BioPortfolio]

Natural history of benign ethnic neutropenia in individuals of African ancestry.

Benign ethnic neutropenia (BEN), defined by neutrophil count

The Natural History of Wilms Tumor - A Case Comparison of Two Different Tumors.

Due to the rarity of Wilms tumor and the relative urgency that pediatric renal tumors are treated, there is little reported data on the natural history and growth of Wilms tumors. Historical reports o...

The Natural History of Choroideraemia.

Since its first description in 1872, there has been a lively academic debate about the natural history of choroideremia. Due to the low prevalence of choroideremia, interest in this discussion has bee...

Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers.

Most glycomics studies have focused on understanding disease mechanisms and proposing serum markers for various diseases, yet the influence of ethnic variation on the identified glyco-biomarker remain...

Neuromuscular Involvement in Glycogen Storage Disease Type III in Fifty Tunisian Patients: Phenotype and Natural History in Young Patients.

 Our aim was to describe the natural history of neuromuscular involvement (NMI) in glycogen storage disease type III (GSDIII).

Clinical Trials [9909 Associated Clinical Trials listed on BioPortfolio]

Research Participants' Views on the Ethics of Clinical Research

This pilot study will explore the usefulness of a series of questions asking about views of research from the perspective of minority and economically disadvantaged research participants. ...

A Natural History Study of Patients With Dry Eye

This is a multi-center, prospective, controlled, observational study of the natural history of patients with dry eye disease.

A Natural History Study of Aspartylglucosaminuria

Aspartylglucosaminuria (AGU) is a rare neurodegenerative lysosomal storage disease (LSD) characterized by developmental delay, psychomotor regression, worsening intellectual disability, ga...

Outcome Measures in Duchenne Muscular Dystrophy: A Natural History Study

Novel emerging therapies for Duchenne Muscular Dystrophy (DMD) require a deeper understanding of DMD natural history. This study aim to assess the natural history of DMD through a composit...

Natural History of Granulomatosis With Polyangiitis: Clinical and Genetic Biomarkers of Airway Disease NoAAC PR-03 Study

The ultimate goal of this prospective natural history study is to define the natural history of the obstructive airway manifestations of Granulomatosis with polyangiitis (GPA). Additional...

Medical and Biotech [MESH] Definitions

A former branch of knowledge embracing the study, description, and classification of natural objects (as animals, plants, and minerals) and thus including the modern sciences of zoology, botany, and mineralogy insofar as they existed at that time. In the 17th, 18th, and 19th centuries it was much used for the generalized pursuit of certain areas of science. (Webster, 3d ed; from Dr. James H. Cassedy, NLM History of Medicine Division)

Comparison of various psychological, sociological, or cultural factors in order to assess the similarities or diversities occurring in two or more different cultures or societies.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Expulsion of a population from a given territory due to religious or ethnic discrimination, political, strategic or ideological considerations, or a combination of these.

Violence or other hostile behavior arising when an ethnic group either feels itself under threat, or where it seeks to assert its superiority or dominance over other groups.

Quick Search


DeepDyve research library

Relevant Topics

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...

Searches Linking to this Article