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Senescence is a cell-fate decision characterized by irreversible arrest of proliferation accompanied by senescence associated secretory phenotype (SASP). Traditionally, cellular senescence was recognized as a beneficial physiological mechanism during development, wound healing, and in tumor suppression. However, in recent years identification of negative consequences of cellular senescence has emerged, illuminating its role in several chronic pathologies. In this context, senescent cells persist or accumulate and have detrimental consequences. In this review, we discuss the possibility that in COPD, persistent senescence impairs wound healing in the lung characterized by secretion of pro-inflammatory SASP factors and exhaustion of progenitor cells. In contrast, in IPF, chronic senescence in alveolar epithelial cells exacerbates the accumulation of senescent fibroblasts along with production of extracellular matrix. We review how cellular senescence may contribute to lung disease pathology.
This article was published in the following journal.
Name: American journal of respiratory cell and molecular biology
Cellular senescence is now considered an important driving mechanism for chronic lung diseases, particularly COPD and idiopathic pulmonary fibrosis. Cellular senescence is due to replicative and stres...
Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors and remodeling proteins (senescence associated secretory phenotype; SASP) that have autocrine a...
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Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
A rapidly growing non-tuberculous environmental mycobacterium causing OPPORTUNISTIC INFECTION that infects the skin and subcutaneous tissues. It is associated with HEALTH CARE ASSOCIATED INFECTION and causes serious lung infections in persons with various chronic lung diseases.
Diseases of domestic and wild horses of the species Equus caballus.
Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza, Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...