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Single-Chain β-D-Glycopyranosylamides of Unsaturated Fatty Acids: Self-Assembly Properties and Applications to Artificial Cell Development.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Single-Chain β-D-Glycopyranosylamides of Unsaturated Fatty Acids: Self-Assembly Properties and Applications to Artificial Cell Development."

Amphiphilic molecules undergo self-assembly in aqueous medium to yield various supramolecular structures depending on their chemical structure and molecular geometry. Among these, lamellar membrane bound vesicles are of special interest due to their resemblance to cellular membranes. Here, we describe the self-assembly of single-chain amide-linked amphiphiles derived from β-D-galactopyranosylamine and various unsaturated fatty acids into vesicles. Fluorescence spectroscopy, X-ray diffraction, and differential scanning calorimetry are used to determine various physical parameters pertinent to the self-assembly process. The vesicular architecture is characterized using optical microscopy and transmission electron microscopy. Moreover, we show that the vesicles derived from these amphiphiles can encapsulate molecules of various sizes and host model biochemical reactions. Our work demonstrates that single-chain glycolipid-based amphiphiles could serve as robust building blocks for artificial cells and have potential applications in drug delivery and microreactor design.

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This article was published in the following journal.

Name: The journal of physical chemistry. B
ISSN: 1520-5207
Pages:

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