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Regio- and Enantioselective Iridium-Catalyzed N-Allylation of Indoles and Related Azoles with Racemic Branched Alkyl-Substituted Allylic Acetates.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Regio- and Enantioselective Iridium-Catalyzed N-Allylation of Indoles and Related Azoles with Racemic Branched Alkyl-Substituted Allylic Acetates."

Rough, Ready and Regioselective. Stable to air, water and SiO2, cyclometallated π-allyliridium C,O-benzoates modified by (S)-tol-BINAP catalyze highly enantioselective N-allylations of indoles and related azoles. Complementing the scope of all previously reported metal-catalyzed indole allylations, complete levels of N vs C3 and branched vs linear regioselectivity are observed.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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Medical and Biotech [MESH] Definitions

Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.

Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.

Five membered rings containing a NITROGEN atom.

Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.

A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.

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