Track topics on Twitter Track topics that are important to you
Rough, Ready and Regioselective. Stable to air, water and SiO2, cyclometallated π-allyliridium C,O-benzoates modified by (S)-tol-BINAP catalyze highly enantioselective N-allylations of indoles and related azoles. Complementing the scope of all previously reported metal-catalyzed indole allylations, complete levels of N vs C3 and branched vs linear regioselectivity are observed.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
A Pd-catalyzed direct C-H trisallylation of azoles with alkyne has been described. A consecutive C(sp2)-H allylation/olefin isomerization/double C(sp3)-H allylation of azoles and alkyne via a palladiu...
An iridium-catalyzed asymmetric allylation of dioxindoles, 3-hydroxyoxindoles, regulated by prosthetic groups has been accomplished under mild conditions. The methodology is applicable to a diverse ar...
The regio- and enantioselective Cu(II)-catalyzed 1,4-conjugate addition of diethylzinc reagent to nitrodienes is described. With 0.25 mol% of Cu(OAc)2 and chiral amidophosphine ligand L3, the 1,4-addi...
An unprecedented acid- and ligand-controlled divergent allylation of indoles with unactivated skipped enynes via Pd hydride catalysis has been disclosed. This redox-neutral transformation went through...
The enantioselective cobalt(III)-catalyzed C-H alkylation was achieved through the design of a novel chiral acid. The cobalt(III)-catalyzed enantioselective C-H activation was characterized by high po...
The specific objective of this study is to compare the relative efficacy of the combination of a temporary iridium implant plus external beam irradiation versus standard external beam irra...
The purpose of this study is to demonstrate the advantage of using a gold alloy tip electrode over a platinum/iridium alloy tip electrode in ablation of the cavotricuspid isthmus in patien...
Candidemia is the most frequent invasive fungal disease in intensive care units (ICUs). It remains a major health concern, considering its attributable mortality up to 40% in critically il...
High dose rate (HDR) brachytherapy is a form of radiation treatment using temporary radioactive seeds. This is done by placing very tiny catheters or tubes into the prostate and then inser...
Acute kidney injury is a common complication of severe Plasmodium knowlesi malaria, and an important contributor to mortality. The exact pathogenic mechanisms of AKI in knowlesi malaria a...
Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.
Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
Five membered rings containing a NITROGEN atom.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.