Changes in white-matter functional network efficiency across the adult lifespan.

08:00 EDT 5th April 2019 | BioPortfolio

Summary of "Changes in white-matter functional network efficiency across the adult lifespan."

Previous studies have used resting-state functional MRI (rs-fMRI) and graph-theory approaches to investigate the lifespan trajectory of the topological organization of the gray-matter functional networks. Recent evidences have suggested that rs-fMRI data can also be used to estimate white-matter function, challenging the conventional practice of taking white-matter signals as noise or artifacts. Here, we examined the correlation between age and white-matter functional network efficiency by applying graph-theory to a large sample of rs-fMRI data of 435 participants. We found that age was correlated negatively with both global and local efficiency of the white-matter functional networks. These findings suggest decreasing white-matter functional network efficiency during the aging process, which provides a complement to conventional gray-matter functional network studies.


Journal Details

This article was published in the following journal.

Name: Neuroreport
ISSN: 1473-558X


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Medical and Biotech [MESH] Definitions

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

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The region of CENTRAL NERVOUS SYSTEM that appears lighter in color than the other type, GRAY MATTER. It mainly consists of MYELINATED NERVE FIBERS and contains few neuronal cell bodies or DENDRITES.

Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)

Region of CENTRAL NERVOUS SYSTEM that appears darker in color than the other type, WHITE MATTER. It is composed of neuronal CELL BODIES; NEUROPIL; GLIAL CELLS and CAPILLARIES but few MYELINATED NERVE FIBERS.

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