Hypoglycemic and hypolipidemic effects of glucomannan extracted from konjac on type 2 diabetic rats.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Hypoglycemic and hypolipidemic effects of glucomannan extracted from konjac on type 2 diabetic rats."

Diabetes and its complications is one of the most concerned metabolic diseases in the worldwide and threaten human health severely. Hypoglycemic and hypolipidemic effects of glucomannan extracted from konjac on high-fat diet and streptozocin-induced type 2 diabetic rats were evaluated in this study. Administration of konjac glucomannan significantly decreased the levels of fasting blood glucose, serum insulin, glucagon-like peptide 1 and glycated serum protein. The concentrations of serum lipids including total cholesterol, triacylglycerols, low-density lipoprotein cholesterol, and non-esterified fatty acid were notably reduced by konjac glucomannan treated. In addition, antioxidant capacity, pancreatic injury and adipose cell hypertrophy were ameliorated by konjac glucomannan administration in type 2 diabetic rats. Besides, UPLC-QTOF MS based lipidomics analysis was used to explore the improvement of lipid metabolic by konjac glucomannan treatment. The disturbance of glycerolipids (diacylglycerol, monoacylglycerol, and triacylglycerol), fatty acyls (acylcarnitine, hydroxyl fatty acid), sphingolipids (ceramide, sphingomyelin) and glycerophospholipids (phosphatidylcholines) metabolism were attenuated for the glucomannan treatment. This study provided a new insight for investigating the anti-diabetic effects of konjac glucomannan and suggest that konjac glucomannan may be a promising nutraceutical for treating type 2 diabetes.


Journal Details

This article was published in the following journal.

Name: Journal of agricultural and food chemistry
ISSN: 1520-5118


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Medical and Biotech [MESH] Definitions

A plant genus of the family LYTHRACEAE. Members contain lagertannin and have hypoglycemic effects.

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