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Diabetes and its complications is one of the most concerned metabolic diseases in the worldwide and threaten human health severely. Hypoglycemic and hypolipidemic effects of glucomannan extracted from konjac on high-fat diet and streptozocin-induced type 2 diabetic rats were evaluated in this study. Administration of konjac glucomannan significantly decreased the levels of fasting blood glucose, serum insulin, glucagon-like peptide 1 and glycated serum protein. The concentrations of serum lipids including total cholesterol, triacylglycerols, low-density lipoprotein cholesterol, and non-esterified fatty acid were notably reduced by konjac glucomannan treated. In addition, antioxidant capacity, pancreatic injury and adipose cell hypertrophy were ameliorated by konjac glucomannan administration in type 2 diabetic rats. Besides, UPLC-QTOF MS based lipidomics analysis was used to explore the improvement of lipid metabolic by konjac glucomannan treatment. The disturbance of glycerolipids (diacylglycerol, monoacylglycerol, and triacylglycerol), fatty acyls (acylcarnitine, hydroxyl fatty acid), sphingolipids (ceramide, sphingomyelin) and glycerophospholipids (phosphatidylcholines) metabolism were attenuated for the glucomannan treatment. This study provided a new insight for investigating the anti-diabetic effects of konjac glucomannan and suggest that konjac glucomannan may be a promising nutraceutical for treating type 2 diabetes.
This article was published in the following journal.
Name: Journal of agricultural and food chemistry
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A plant genus of the family LYTHRACEAE. Members contain lagertannin and have hypoglycemic effects.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
A plant genus of the family ARACEAE. Members contain konjac glucomannan (MANNANS) and SEROTONIN.
Derivatives of biguanide (the structure formula HN(C(NH)NH2)2) that are primarily used as oral HYPOGLYCEMIC AGENTS for the treatment of DIABETES MELLITUS, TYPE 2 and PREDIABETES.
A purine and quinazoline derivative that functions as an INCRETIN and DIPEPTIDYL-PEPTIDASE IV INHIBTOR. It is used as a HYPOGLYCEMIC AGENT in the treatment of TYPE II DIABETES MELLITUS.
Diabetes is a lifelong condition that causes a person's blood sugar level to become too high. The two main types of diabetes are: type 1 diabetes type 2 diabetes In the UK, diabetes affects approximately 2.9 million people. There are a...