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Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis Toward Autonomous Decision Making.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis Toward Autonomous Decision Making."

Microphysiological systems replicate human organ function, and are promising technologies for discovery of translatable biomarkers, pharmaceuticals, and regenerative therapies. Because microphysiological systems require complex microscale anatomical structures and heterogeneous cell populations, a major challenge remains to manufacture and operate these products with reproducible and standardized function. In this Perspective, three stages of microphysiological system monitoring, including process, development, and function, are assessed. The unique features and remaining technical challenges for the required sensor are discussed. Monitoring of microphysiological systems require non-destructive, continuous biosensors and imaging techniques. With such tools, the extent of cellular and tissue development, as well as function, can be autonomously determined and optimized by correlating physical and chemical sensor outputs with markers of physiological performance. Ultimately, data fusion and analyses across process, development, and function monitors can be implemented to will enable the adoption of microphysiological systems for broad research and commercial applications.

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This article was published in the following journal.

Name: ACS sensors
ISSN: 2379-3694
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