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Material cues to influence cell proliferation are a fundamental issue in the fields of Biomaterials, Cell Biology, Tissue Engineering and Regenerative Medicine. This paper aims to investigate proliferation of single mammal cells on micropatterned material surfaces. To this end, we prepared cell-adhesive circular microislands with 20 areas on the non-fouling background, and systematically examined adhesion and proliferation behaviors of different kinds of single cells (primary stem and non-stem cells, cancer and normal cell lines) on micropatterns. Based on the analysis of experimental data, we found two critical areas about cell proliferation: (1) the critical spreading area of cells from almost no proliferation to confined proliferation, denoted as A, (2) the critical spreading area of cells from confined proliferation to almost free proliferation, denoted as A. We further summarized the relative size relationship between these two critical areas and the characteristic areas about cell adhesion both on patterned and non-patterned surfaces. While proliferation of single primary cells was affected by cell spreading, those cell lines, irrespective of normal and cancer cells, did not exhibit significant cell spreading effects. As a result, this study reveals that proliferation of single cells is dependent upon spreading area, in particular for primary cells on material surfaces.
This article was published in the following journal.
Name: ACS applied materials & interfaces
In this study, we evaluated the effects of ultraviolet (UV) treatment and alendronate (ALN) immersion on the proliferation and differentiation of MG-63 osteoblast-like cells and human gingival fibrobl...
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Cellular responses on a topographic surface are fundamental topics about Interfaces and Biology. Herein, a poly(lactide-co-glycolide) (PLGA) micropillar array was prepared and found to trigger signifi...
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To investigate effects of soft, sand and hard surfaces on functional ability and falls in elderly with or without history of multiple falls.
A replica technique in which cells are frozen to a very low temperature and cracked with a knife blade to expose the interior surfaces of the cells or cell membranes. The cracked cell surfaces are then freeze-dried to expose their constituents. The surfaces are now ready for shadowing to be viewed using an electron microscope. This method differs from freeze-fracturing in that no cryoprotectant is used and, thus, allows for the sublimation of water during the freeze-drying process to etch the surfaces.
The surgical fixation of a joint by a procedure designed to accomplish fusion of the joint surfaces by promoting the proliferation of bone cells. (Dorland, 28th ed)
A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
The dependence of tumor cells on a single oncogenic pathway or protein for their continued proliferation and survival.
A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.
Track and monitor developments in stem cell research and commercial development. Follow the tabs above to read the latest global news, research, clinical trials on stem cells and follow companies active in the stem cell industry. BioPort...