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NIR-Triggered Exogenous Enzymes to Convert Prodrugs for Locoregional Chemo-Photothermal Therapy.

08:00 EDT 9th April 2019 | BioPortfolio

Summary of "NIR-Triggered Exogenous Enzymes to Convert Prodrugs for Locoregional Chemo-Photothermal Therapy."

Enzymes have been mostly explored to direct the conversion of the prodrugs in cancer therapy. However, non-specific distribution of endogenous enzymes seriously hinders their bioapplications. Herein, we developed a near-infrared light response locoregional chemo-photothermal therapy based on the exogenous enzyme delivery and remolded tumor microenvironment after irradiation. The catalytic efficiency of enzymes was enhanced by the hyperthermia, and the efficacy of photothermal therapy (PTT) was improved due to the inhibition of heat shock protein 90 by chemotherapeutics. The locoregional chemo-phototherapy achieved a one-time successful cure in 4T1 tumor-bearing mice model. Thus, a mutually reinforcing feedback loop exists between PTT and chemotherapy can be initiated by the irradiation, which holds a promising future in cancer therapy.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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