Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease."

Hirschsprung's disease, or congenital aganglionosis, is a developmental disorder of the enteric nervous system and is the most common cause of intestinal obstruction in neonates and infants. The disease has more than 80% heritability, including significant associations with rare and common sequence variants in genes related to the enteric nervous system, as well as with monogenic and chromosomal syndromes.


Journal Details

This article was published in the following journal.

Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 1421-1432


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