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Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease."

Prodromal Alzheimer's disease offers an opportunity to test the effect of drugs that modify the deposition of amyloid in the brain before the onset of dementia. Verubecestat is an orally administered β-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) inhibitor that blocks production of amyloid-beta (Aβ). The drug did not prevent clinical progression in a trial involving patients with mild-to-moderate dementia due to Alzheimer's disease.

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Journal Details

This article was published in the following journal.

Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 1408-1420

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