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Given the superior penetration depth, photosensitizer with longer absorption wavelength presents broader application prospect in photodynamic therapy (PDT). Herein, Ag2S quantum dot was discovered, for the first time, to be capable of killing tumor cell in the photodynamic way by near-infrared light irradiation, which meant relative less excitation of probe compared with traditional photosensitizer absorbing short wavelength. With further modification of polydopamine (PDA), the outstanding capacity of PDA-Ag2S inducing reactive oxygen species was obtained which increased by 1.69 times. With the regulation of PDA, more opportunities were provided for Ag2S to react with surrounding O2 demonstrated by the typical triplet electron spin resonance (ESR). Furthermore, the PDT effects of Ag2S and PDA-Ag2S achieved at longer wavelength were almost identical to the effects produced at 660 nm proved by studies in vitro. And distinctly better therapeutic phenomenon of PDA-Ag2S than Ag2S was shown in experiments in vivo, which further validated the enhanced regulatory effect of PDA. Together, a new photosensitizer with longer absorption wavelength was developed, with the hitherto-unexplored photodynamic function of Ag2S quantum dot extended and its enhanced regulatory effect originated from PDA.
This article was published in the following journal.
Name: Chemistry (Weinheim an der Bergstrasse, Germany)
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The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.
A complex mixture of monomeric and aggregated porphyrins used in the photodynamic therapy of tumors (HEMATOPORPHYRIN PHOTORADIATION). A purified component of this mixture is known as DIHEMATOPORPHYRIN ETHER.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
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Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.