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Angular vestibulo-ocular reflex responses in Otop1 mice. II. Otolith sensor input improves compensation after unilateral labyrinthectomy.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Angular vestibulo-ocular reflex responses in Otop1 mice. II. Otolith sensor input improves compensation after unilateral labyrinthectomy."

The role of the otoliths in mammals on the normal angular vestibulo-ocular reflex (VOR) was characterised in an accompanying study based on the Otopetrin1 (Otop1) mouse, which lacks functioning otoliths due to failure to develop otoconia but seems to have otherwise normal peripheral anatomy and neural circuitry. That study showed that otoliths do not contribute to the normal horizontal (rotation about Earth-vertical axis parallel to dorso-ventral axis) and vertical angular VOR (rotation about Earth-vertical axis parallel to inter-aural axis), but do affect gravity context-specific VOR adaptation. By using these animals, we sought to determine whether the otoliths play a role in the angular VOR after unilateral labyrinthectomy when the total canal signal is reduced. In 5 Otop1 and 5 control littermates we measured horizontal and vertical left-ear-down (LED) and (RED) sinusoidal VOR (0.2-10Hz, 20-100°/s) during the early (3-5 days) and plateau (28-32 days) phases of compensation following unilateral labyrinthectomy and compared these measurements with baseline preoperative responses from the accompanying study. From similar baselines, acute gain loss was ~25% less in control mice, and chronic gain recovery was ~40% more in control mice. The acute data suggest that the otoliths contribute to the angular VOR when there is a loss of canal function. The chronic data suggest that a unilateral otolith signal can significantly improve angular VOR compensation. These data have implications for vestibular rehabilitation of patients with both canal and otolith loss and the development of vestibular implants, which currently only mimic the canals on one side.

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This article was published in the following journal.

Name: Journal of neurophysiology
ISSN: 1522-1598
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