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Targeted Delivery of Zoledronate To Tumor Associated Macrophages For Cancer Immunotherapy.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Targeted Delivery of Zoledronate To Tumor Associated Macrophages For Cancer Immunotherapy."

Tumor associated macrophages (TAMs) are recruited from circulatory monocytes by tumor derived factors, which differentiate into macrophages residing in tumor microenvironment. They play critical roles in promoting angiogenesis, invasion, metastasis and immune escape and direct depletion of TAMs will be a promising strategy for tumor immunotherapy. In this study, we developed lipid coated calcium zoledronate nanoparticles (CaZol@pMNPs) containing mannose conjugation, sterically shielded with a extracellular pH sensitive material. The nanoparticles could specially target to TAMs and induce their apoptosis in vitro and in vivo. In a S180 tumor bearing mice model, CaZol@pMNPs effectively demonstrated TAMs depletion, remarkably decreased angiogenesis, reduced immune suppression and eventually restrained tumor growth, without eliciting systemic effects. Taken together, these data demonstrated the potential of direct depletion of TAMs using CaZol@pMNPs for cancer immunotherapy.

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This article was published in the following journal.

Name: Molecular pharmaceutics
ISSN: 1543-8392
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