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Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-Type Heterostructures of Au-Bi2S3 Nanoparticles via X-Ray-Induced Catalytic Reaction for Radiosensitization.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-Type Heterostructures of Au-Bi2S3 Nanoparticles via X-Ray-Induced Catalytic Reaction for Radiosensitization."

Despite the development of nanomaterials with high-Z elements for radiosensitizers, most of them are suffering from their oxygen-dependent behavior in hypoxic tumor, non-ideal selectivity to tumor or inevasible damages to normal tissue, greatly limiting their further applications. Herein, we develop a Schottky-type heterostructure of Au-Bi2S3 with promising ability of reactive free radicals generation under X-ray irradiation for selectively enhancing radiotherapeutic efficacy by catalyzing intracellular H2O2 in tumor. On the one hand, like many other nanomaterials with rich high-Z elements, Au-Bi2S3 can deposit higher radiation dose within tumors in the form of high energy electrons. On the other hand, Au-Bi2S3 can remarkably improve the utilization of a large number of X-ray-induced low energy electrons during radiotherapy for non-oxygen dependent free radicals generation even in hypoxic condition. This feature of Schottky-type heterostructures Au-Bi2S3 attributes to the generated Schottky barrier between metal Au and semiconductor Bi2S3 which can trap the X-ray-generated electrons and transfer them to Au, resulting in efficient separation of the electron-hole pairs. Then, because of the matched potential between the conduction band of Bi2S3 and overexpressed H2O2 within tumor, the Au-Bi2S3 HNSCs can decompose the intracellular H2O2 into highly toxic •OH for selective radiosensitization in tumor. As a consequence, this kind of nanoparticle provides an idea to develop rational designed Schottky-type heterostructures as efficient radiosensitizers for enhanced radiotherapy of cancer.

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Name: ACS nano
ISSN: 1936-086X
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