S-nitrosylation of cytoskeletal proteins.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "S-nitrosylation of cytoskeletal proteins."

Nitric oxide has pronounced effects on cellular functions normally associated with the cytoskeleton, including cell motility, shape, contraction, and mitosis. Protein S-nitrosylation, the covalent addition of a NO group to a cysteine sulfur, is a signaling pathway for nitric oxide that acts in parallel to cyclic-GMP, but is poorly studied compared to the latter. There is growing evidence that S-nitrosylation of cytoskeletal proteins selectively alters their function. We review that evidence, and find that S-nitrosylation of cytoskeletal targets has complementary but distinct effects to cyclic-GMP in motile and contractile cells - promoting cell migration, and biasing muscle contraction toward relaxation. However, the effects of S-nitrosylation on a host of cytoskeletal proteins and functions remains to be explored. This article is protected by copyright. All rights reserved.


Journal Details

This article was published in the following journal.

Name: Cytoskeleton (Hoboken, N.J.)
ISSN: 1949-3592


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