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Rapid synthesis and anti-proliferative properties of polyazamacrocycle-based bi- and tetra-gold(I) phosphine dithiocarbamate complexes.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Rapid synthesis and anti-proliferative properties of polyazamacrocycle-based bi- and tetra-gold(I) phosphine dithiocarbamate complexes."

A family of bimetallic and of tetrametallic phosphine-gold(I)-dithiocarbamate complexes were synthesized starting from cyclam and dimethylcyclam polyazamacrocycles respectively, along with their monometallic chlorido-phosphine gold(I) precursors. Their antiproliferative properties were evaluated on two cancer cell lines (A549 and NSCLC-N6-L16). Most of the mono and bimetallic complexes displayed strong activities, and especially one bimetallic derivatives showed anti-proliferative properties in the low micromolar range. Insights in the structure activity relationships were given, along with determination of thioredoxin reductase inhibition potential, two-photon imaging of the fluorescent derivatives, and evaluation of gold uptake.

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This article was published in the following journal.

Name: Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
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