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Hydrazide-hydrazone Small Molecules as AIEgens: Illuminating Mitochondria in Cancer Cells.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Hydrazide-hydrazone Small Molecules as AIEgens: Illuminating Mitochondria in Cancer Cells."

Aggregation induced emission probes (AIEgens) have gained lots of attention as interesting tools for ample biomedical applications especially bio-imaging due to their brightness and photo-stability. Numerous AIEgens have been developed for lighting up the sub-cellular organelles to understand their forms and functions in healthy as well as diseased states like cancer. However, there is a serious absence of easily synthesizable, biocompatible small molecules for illuminating mitochondria (powerhouses) inside cells. To address this, in this report we describe an easy and short synthesis of novel biocompatible hydrazide-hydrazone based small molecules with remarkable aggregation-induced emission (AIE) property. These small molecule AIEgens showed hitherto unobserved AIE property due to dual intra-molecular H-bonding confirmed by theoretical calculation, pH and temperature dependent fluorescence and X-ray crystallography studies. Confocal microscopy showed that these AIEgens were internalized into the HeLa cervical cancer cells without showing any cytotoxicity. One of the AIEgens was tagged with triphenylphosphine (TPP) moiety which successfully localized into mitochondria of HeLa cells selectively compared to L929 non-cancerous fibroblast cells. These unique hydrazide-hydrazone based biocompatible AIEgens can serve as powerful tools to illuminate multiple sub-cellular organelles to elucidate their forms and functions in cancer cells for next-generation biomedical applications.

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This article was published in the following journal.

Name: Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
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