Hydrazide-hydrazone Small Molecules as AIEgens: Illuminating Mitochondria in Cancer Cells.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Hydrazide-hydrazone Small Molecules as AIEgens: Illuminating Mitochondria in Cancer Cells."

Aggregation induced emission probes (AIEgens) have gained lots of attention as interesting tools for ample biomedical applications especially bio-imaging due to their brightness and photo-stability. Numerous AIEgens have been developed for lighting up the sub-cellular organelles to understand their forms and functions in healthy as well as diseased states like cancer. However, there is a serious absence of easily synthesizable, biocompatible small molecules for illuminating mitochondria (powerhouses) inside cells. To address this, in this report we describe an easy and short synthesis of novel biocompatible hydrazide-hydrazone based small molecules with remarkable aggregation-induced emission (AIE) property. These small molecule AIEgens showed hitherto unobserved AIE property due to dual intra-molecular H-bonding confirmed by theoretical calculation, pH and temperature dependent fluorescence and X-ray crystallography studies. Confocal microscopy showed that these AIEgens were internalized into the HeLa cervical cancer cells without showing any cytotoxicity. One of the AIEgens was tagged with triphenylphosphine (TPP) moiety which successfully localized into mitochondria of HeLa cells selectively compared to L929 non-cancerous fibroblast cells. These unique hydrazide-hydrazone based biocompatible AIEgens can serve as powerful tools to illuminate multiple sub-cellular organelles to elucidate their forms and functions in cancer cells for next-generation biomedical applications.


Journal Details

This article was published in the following journal.

Name: Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765


DeepDyve research library

PubMed Articles [22442 Associated PubMed Articles listed on BioPortfolio]

Highly photostable two-photon NIR AIEgens with tunable organelle specificity and deep tissue penetration.

Photostability is a particularly important parameter for fluorescence imaging especially long-term dynamic tracking in live samples. However, many organic fluorophores show poor photostability under o...

AIEgen based drug delivery systems for cancer therapy.

Fluorescent drug delivery systems provide a means to track drug release, trace processes of translocation, monitor excretion of anticancer agents and predict therapeutic responses. Traditional fluores...

Enhancing the kinetics of hydrazone exchange processes: an experimental and computational study.

The capacity of hydrazone bonds to readily undergo component exchange processes sees their extensive utilization in dynamic combinatorial chemistry. The kinetics of hydrazone exchange are optimal at p...

KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer.

The GTPase KRas4B has been utilized as a principal target in the development of anticancer drugs. PDE6δ transports KRas4B to the plasma membrane, where it is released to activate various signaling pa...

Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-based and mitochondria-targeted prooxidative anticancer theranostic prodrugs.

Developing concise theranostic prodrugs is highly desirable for personalized and precision cancer therapy. Herein we used the glutathione (GSH)-mediated conversion of 2,4-dinitrobenzenesulfonates to p...

Clinical Trials [13437 Associated Clinical Trials listed on BioPortfolio]

Clinical Study of Mitochondria-targeted System Therapy Combined With Radiofrequency Ablation for Early-stage Non-small Cell Lung Cancer

Lung cancer is the leading cause of cancer related mortality. Among them, non small cell lung cancer accounts for 85%. Only part of patients could be treated with radical surgery. Mitochon...

CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle

This study will test if inhalation of Carbon Monoxide (CO) will increase the numbers of mitochondria in heart muscle. Mitochondria are the small components of muscle and other cells that c...

Cellular Pharmacodynamics of Small Molecules in Lysosomal Storage Disorders

The purpose of this study is to evaluate the effect of small molecule therapy in primary cells derived from patients with lysosomal storage disease. The study will focus on activity of sma...

Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality.

Embryo quality was ranked as one of the most important predictors in determining the success of implantation, while clinically some patients may experience repeated IVF failure due to pers...

Mitochondria Inborn Errors of Metabolism and ANT Defects in Mitochondria Diseases

The objective of this research protocol is to continue investigation of the nature and prevalence of mitochondria disease and to aid patients and health care providers in the understanding...

Medical and Biotech [MESH] Definitions

Fat cells with dark coloration due to the densely packed MITOCHONDRIA. They contain numerous small lipid droplets or vacuoles. Their stored lipids can be converted directly to energy as heat by the mitochondria.

Mitochondria of skeletal and smooth muscle. It does not include myocardial mitochondria for which MITOCHONDRIA, HEART is available.

Organelles in which the splicing and excision reactions that remove introns from precursor messenger RNA molecules occur. One component of a spliceosome is five small nuclear RNA molecules (U1, U2, U4, U5, U6) that, working in conjunction with proteins, help to fold pieces of RNA into the right shapes and later splice them into the message.

A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).

Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).

Quick Search


DeepDyve research library

Relevant Topics

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Searches Linking to this Article