Acute ethanol produces ataxia and induces Fmr1 expression via histone modifications in the rat cerebellum.

08:00 EDT 10th April 2019 | BioPortfolio

Summary of "Acute ethanol produces ataxia and induces Fmr1 expression via histone modifications in the rat cerebellum."

The cerebellum is fundamental for motor coordination and therefore crucial in ethanol-induced ataxia. Ethanol contributes to cerebellar pathophysiology. Fragile-X Mental Retardation protein (FMRP) is a complex regulator of RNA and synaptic plasticity implicated in Fragile-X Tremor and Ataxia Syndrome, a phenotype featuring increased Fmr1 mRNA expression. Recent studies have implicated glutamatergic targets of FMRP in hereditary cerebellar ataxias including the main cerebellar excitatory amino acid (Eaa1) transporter and a subtype of metabotropic glutamate receptor (Grm5). However, ethanol-induced changes in cerebellar Fmr1 expression and its epigenetic regulation have not been investigated. Here, we examined the effects of acute ethanol exposure on ataxic behavior, gene expression, and epigenetic regulation of the Fmr1 gene and its glutamatergic targets in the rat cerebellum.


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This article was published in the following journal.

Name: Alcoholism, clinical and experimental research
ISSN: 1530-0277


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