Influence of smoking on CYP2C19 genetic variants and clopidogrel efficacy in patients with minor stroke or TIA.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Influence of smoking on CYP2C19 genetic variants and clopidogrel efficacy in patients with minor stroke or TIA."

Studies suggest that smoking affects clopidogrel efficacy. However, whether it influences the association between CYP2C19 genetic variants and clopidogrel efficacy is not clear.


Journal Details

This article was published in the following journal.

Name: European journal of neurology
ISSN: 1468-1331


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Medical and Biotech [MESH] Definitions

Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19.

Drugs and compounds that induce the synthesis of CYTOCHROME P-450 CYP2C19.

A decrease in the incidence and frequency of SMOKING. Smoking reduction differs from SMOKING CESSATION in that the smoker continues to smoke albeit at a lesser frequency without quitting.

Pipes for smoking tobacco, cannabis, and other substances, in which smoke is drawn through water. Do not confuse with SMOKING PIPES.

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