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Effects of Enantiomerically Pure β-Carboline Alkaloids from Picrasma quassioides on Human Hepatoma Cells.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Effects of Enantiomerically Pure β-Carboline Alkaloids from Picrasma quassioides on Human Hepatoma Cells."

Four pairs of -carboline enantiomers (1
A:
/1
B:
-4
A:
/4
B:
), 2 -carboline derivatives (5:  - 6: ) with a single enantiomeric configuration, together with 2 known achiral congeners (7:  - 8: ) were isolated from the stems of Their structures were elucidated on the basis of extensive spectroscopic analyses and quantum mechanical calculations. Compound 5: possesses a 4,5-seco -carboline framework and represents the first example of this type of -carboline alkaloids from nature. A possible biosynthetic pathway is proposed to generate the racemate 4: and the enantiomerically pure compounds 5: and 6: . All isolates were screened for their cytotoxicity against hepatocellular carcinoma Hep3B and HepG2 cells, which revealed that enantiomeric compounds 4
A:
and 4
B:
had distinctive effects in HepG2 cells. Further investigation showed that 4
B:
could induce apoptosis in HepG2 cells.

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Journal Details

This article was published in the following journal.

Name: Planta medica
ISSN: 1439-0221
Pages:

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