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Four pairs of -carboline enantiomers (1
), 2 -carboline derivatives (5: - 6: ) with a single enantiomeric configuration, together with 2 known achiral congeners (7: - 8: ) were isolated from the stems of Their structures were elucidated on the basis of extensive spectroscopic analyses and quantum mechanical calculations. Compound 5: possesses a 4,5-seco -carboline framework and represents the first example of this type of -carboline alkaloids from nature. A possible biosynthetic pathway is proposed to generate the racemate 4: and the enantiomerically pure compounds 5: and 6: . All isolates were screened for their cytotoxicity against hepatocellular carcinoma Hep3B and HepG2 cells, which revealed that enantiomeric compounds 4
had distinctive effects in HepG2 cells. Further investigation showed that 4
could induce apoptosis in HepG2 cells.
This article was published in the following journal.
Name: Planta medica
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Alkaloids with powerful hypotensive effects isolated from American or European Hellebore (Veratrum viride Ait. Liliaceae and Veratrum album L. Liliaceae). They increase cholinergic and decrease adrenergic tone with appropriate side effects and at higher doses depress respiration and produce cardiac arrhythmias; only the ester alkaloids have been used as hypotensive agents in specific instances. They have been generally replaced by drugs with fewer adverse effects.
Alkaloids found in OPIUM from PAPAVER that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS.
Compounds formed by condensation of secologanin with tryptamine resulting in a tetrahydro-beta-carboline which is processed further to a number of bioactive compounds. These are especially found in plants of the APOCYNACEAE; LOGANIACEAE; and RUBIACEAE families.
Measurement of hearing based on the use of pure tones of various frequencies and intensities as auditory stimuli.
A plant genus of the family SIMAROUBACEAE. Members contain javanicins, picrasinoside and other quassinoids.