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Parabens are ubiquitous substances commonly used as preservatives because of their antibacterial activity. The estrogenic activity of parabens may cause undesirable health effects and adverse birth outcomes. The objective of the present systematic review was to investigate the association between prenatal exposure to parabens and anthropometric birth outcomes. PubMed, Web of Science, Scopus, and Embase databases were systematically searched until April 18, 2018. Of 326 records that remained after removing duplicates, 6 original articles were included in the final analysis after excluding irrelevant articles. The included studies indicated that most of the pregnant mothers were exposed to parabens, especially methyl and propyl parabens. However, no definitive association was found between the prenatal urinary concentration of parabens and birth weight or head circumference. In addition, a positive but non-significant association was detected between birth length and maternal exposure to parabens. The present systematic review revealed that assessment of significant associations in current epidemiological studies is impermissible due to methodological limitations and absence of inter-study consistency. Furthermore, because of the complexity of the effect of environmental factors on health, future large-scale studies with proper study design are required to investigate the effect of parabens exposure on birth outcomes.
This article was published in the following journal.
Name: Environmental research
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The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
Review of the medical necessity of hospital or other health facility admissions, upon or within a short time following an admission, and periodic review of services provided during the course of treatment.
Determination of the nature of a pathological condition or disease in the postimplantation embryo, fetus, or pregnant female before birth.
Multi-step systematic review process used for improving safety by investigation of incidents to find what happened, why it happened, and to determine what can be done to prevent it from happening again.
Formal programs for assessing drug prescription against some standard. Drug utilization review may consider clinical appropriateness, cost effectiveness, and, in some cases, outcomes. Review is usually retrospective, but some analysis may be done before drugs are dispensed (as in computer systems which advise physicians when prescriptions are entered). Drug utilization review is mandated for Medicaid programs beginning in 1993.
Obstetrics and gynaecology
Fertility Menopause Obstetrics & Gynaecology Osteoporosis Women's Health Obstetrics and gynaecology comprises the care of the pregnant woman, her unborn child and the management of diseases specific to women. Most consultant...
Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...