Track topics on Twitter Track topics that are important to you
Octocrylene is used as UV filter in personal care products with a high production volume and can be detected in surface water and biota. It is liquid at ambient temperature, highly lipophilic, has a high adsorption capacity to organic material and is considered as persistent in the environment. The very low water solubility complicates the evaluation of potential long-term effects in aquatic toxicity testing, since effect thresholds are often above the water solubility limit. Thus, the evaluation of the bioaccumulation potential becomes highly relevant for the assessment of long-term environmental effects. However, even the determination of the water solubility limit for a substance with such difficult properties is challenging. The following experiments are described, and results compared to available environmental monitoring data: A bioconcentration study with aqueous exposure (BCF) in zebrafish and a biomagnification study with dietary exposure (BMF) in rainbow trout, as well as supporting experiments to evaluate the water solubility. The growth and lipid corrected BCF determined by aqueous exposure was 858 L kg while the corrected BMF was 0.0335. The model-based estimation of the BCF from BMF (152-1182 L kg) is in good agreement with the measured BCF value. Environmental monitoring data provide only limited information on the bioaccumulation potential of octocrylene, as only few investigations were made in biota and water in parallel and concentrations of octocrylene vary by several orders of magnitude during seasons. Based on the determined fish BCF data, we conclude that OCR is not bioaccumulative according to the criteria as laid down by ECHA, 2017. Furthermore, the low BMF value indicates no accumulation along the food chain.
This article was published in the following journal.
Name: The Science of the total environment
The bioaccumulation, cell, tissue distribution, and biological effects of 5 nm glutathione-capped CdS quantum dots (CdS QDs) in mussels was compared to bulk and aqueous Cd forms through a two-tier e...
We performed accumulation-elimination experiments of polycyclic aromatic compounds (PACs) in wood frog tadpoles (Lithobates sylvaticus) using river sediment from Canada's Athabasca oil sands region. T...
Lead (Pb) is a highly toxic metal in aquatic environments. Fish are at the top of the food chain in most aquatic environments, and are the most susceptible to the toxic effects of Pb exposure. In addi...
The objective of this study is to determine if consumption of fish and other dietary elements are related to the serum PCB levels of a group of adolescents. A dietary pattern approach is used to provi...
Biomagnification of hydrophobic organic compounds (HOCs) increases the eco-environmental risks they pose. Here, we gained mechanistic insights into biomagnification of deuterated polycyclic aromatic h...
This study is designed to assess the systemic exposure and pharmacokinetics of sunscreen active ingredients (avobenzone, oxybenzone, ecamsule and octocrylene) when sunscreen product is app...
The AM-HTN trial aim to investigate the effects of a tablet based on aqueous extracts of Annona muricata as add-on therapy in a hypertensive population. Patients with prehypertension or s...
The purpose of this study is to obtain and assay human aqueous samples following pre-operative dosing with 0.1% Brimonidine Purite™ (pH 7.8) or with 0.15% Brimonidine Purite® (pH 7.2) f...
The purpose of this study is to evaluate the penetration of levofloxacin and dexamethasone 21-phosphate into the aqueous humour after ocular administration in combination or as single acti...
Comparison of aqueous and plasma glucose level in diabetic patients High glucose concentrations in aqueous humor are thought to be related of diabetic ocular injury, including cataract an...
The exposure to potentially harmful factors such as trace heavy metals, chemicals, radiation, or toxins due to FOOD CONTAMINATION including DRINKING WATER contamination.
Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
A self-evaluation of health status.
Collaborations in biotechnology
Commercial and academic collaborations are used throughout the biotechnology and pharmaceutical sector to enhance research and product development. Collaborations can take the form of research and evaluation agreements, licensing, partnerships etc. ...