MRI reveals a pronounced treatment response of a IDH- and BRAF-wildtype epithelioid glioblastoma.

08:00 EDT 8th April 2019 | BioPortfolio

Summary of "MRI reveals a pronounced treatment response of a IDH- and BRAF-wildtype epithelioid glioblastoma."

We here report MRI findings in a 60-year old patient with an epithelioid glioblastoma of the corpus callosum treated with radiotherapy in combination with concomitant and adjuvant temozolomide. Neuropathology revealed a highly aggressive molecular subtype of the epithelioid glioblastoma without an IDH and BRAF mutation or a MGMT promoter hypermethylation. This subtype is typically associated with an unfavorable clinical course and poor overall survival. Unexpectedly, the first follow-up MRI 10 weeks after chemoradiation completion revealed an early and almost complete treatment response.


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Name: World neurosurgery
ISSN: 1878-8769


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