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Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats.

08:00 EDT 8th April 2019 | BioPortfolio

Summary of "Postnatal early overfeeding induces cardiovascular dysfunction by oxidative stress in adult male Wistar rats."

Obesity is associated with innumerous comorbidities, including cardiovascular diseases, that occur by various mechanisms, including hyperactivation of the renin angiotensin system, oxidative stress and cardiovascular overload. Postnatal early overfeeding (PO) leads to metabolic imprinting that induces weight gain throughout life, and in this paper, we aimed to evaluate cardiovascular parameters and cardiac molecular changes due to obesity induced early in life by PO.

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Name: Life sciences
ISSN: 1879-0631
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A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

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