Epithelium-derived Cystatin-SN enhances eosinophil activation and infiltration via interleukin-5 in chronic rhinosinusitis with nasal polyps.

08:00 EDT 8th April 2019 | BioPortfolio

Summary of "Epithelium-derived Cystatin-SN enhances eosinophil activation and infiltration via interleukin-5 in chronic rhinosinusitis with nasal polyps."

The interaction between epithelial cells and immune cells plays an important role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP); however, the mechanism/s underlying TH-biased inflammation in this process is/are largely unknown. Profiling protein expression in CRSwNP by shotgun proteomics suggested that Cystatin SN (CST1), a type 2 cysteine protease inhibitor, may play a role, as this was expressed with greatest difference in eosinophilic (E)CRSwNP and nonECRSwNP patients.


Journal Details

This article was published in the following journal.

Name: The Journal of allergy and clinical immunology
ISSN: 1097-6825


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Medical and Biotech [MESH] Definitions

A 19-kDa cationic peptide found in EOSINOPHIL granules. Eosinophil-derived neurotoxin is a RIBONUCLEASE and may play a role as an endogenous antiviral agent.

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.

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