Chiral Brønsted acid catalyzed metal free asymmetric direct reductive amination using 1-hydrosilatrane.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Chiral Brønsted acid catalyzed metal free asymmetric direct reductive amination using 1-hydrosilatrane."

The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-hydrosilatrane with a chiral Brønsted acid catalyst is reported. This is the first known example of chiral Brønsted acid catalyzed asymmetric reductive amination using a silane as the hydride source. The reaction features a highly practical reducing reagent and proceeds efficiently at room temperature without specialized reaction setup or equipment to exclude air or moisture. This method provides high conversion and ees up to 84% of the desired chiral secondary amines with minimal side products.


Journal Details

This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904


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