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Development of an anti-BAG3 humanized antibody for treatment of pancreatic cancer.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Development of an anti-BAG3 humanized antibody for treatment of pancreatic cancer."

We have previously shown that secreted BAG3 is a potential target for treatment of pancreatic ductal adenocarcinoma, and that pancreatic tumor growth and metastatic dissemination can be reduced by treatment with an anti-BAG3 murine antibody. Here, we used complementarity-determining region (CDR) grafting to generate a humanized version of the anti-BAG3 antibody that may be further developed for possible clinical use. We show that the humanized anti-BAG3 antibody, named BAG3-H2L4, abrogates BAG3 binding to macrophages and subsequent release of IL-6. Furthermore, it specifically localizes into tumor tissues and significantly inhibits the growth of MiaPaCa-2 pancreatic cancer cell xenografts. We propose BAG3-H2L4 antibody as a potential clinical candidate for BAG3-targeted therapy in pancreatic cancer.

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This article was published in the following journal.

Name: Molecular oncology
ISSN: 1878-0261
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