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Synchronized On/Off Switching of Four Binding Sites for Water in a Molecular Solomon Link.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Synchronized On/Off Switching of Four Binding Sites for Water in a Molecular Solomon Link."

A molecular Solomon link (SL) adopts different conformations in acetonitrile (1) and in water (2). Contrary to expectations, the main driving force of the transformation is not the change in medium polarity, but the cooperative binding of ca. 4 molecules of water, forming a tiny droplet in the central cavity of 2. Mechanistic studies reveal that the four binding sites can simultaneously switch between an inactive state (unable to bind water) and an active state (able to bind water) during the transformation. Spatial and temporal coordination of switching events is commonly observed in biological systems but has been rarely achieved in artificial systems. Here, the coordinated activation of the four switchable sites is controlled by the topology of the whole molecule.

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Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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