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Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis.

08:00 EDT 11th April 2019 | BioPortfolio

Summary of "Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis."

A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations.

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Name: Chemical communications (Cambridge, England)
ISSN: 1364-548X
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