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The goal of radiation therapy is to deliver tumoricidal dose to clinical target volume (CTV) while sparing organs-at-risk (OAR). We hypothesize that the joint use of proton and photon radiation therapy via appropriate hybrid proton-photon inverse planning method will be more favorable than proton or photon therapy alone, in terms of optimized combination of CTV coverage and OAR sparing. This work develops hybrid proton-photon inverse optimization method that simultaneously optimizes proton and photon variables. To account for delivery uncertainty, proton dose is targeted at CTV using robust optimization, and photon dose is targeted at either CTV using robust optimization or planning target volume (PTV) using the same setup shifts. The optimization objectives enforce OAR sparing and uniform CTV coverage for the total dose, while imposing uniform-dose regularization at targets for both the proton and photon component in order for both components to be individually deliverable. The hybrid problem with dose-volume-histogram (DVH) constraints is nonconvex and solved by iterative convex relaxations of DVH constraints and alternating direction method of multipliers (ADMM). Preliminary results suggest the hybrid proton-photon planning potentially improves proton or photon planning in terms of optimized combination of CTV coverage and OAR sparing.
This article was published in the following journal.
Name: Physics in medicine and biology
Photon-limited imaging has significant application under extreme environments, in which the photon efficiency is an important parameter. In this paper, we investigate the photon efficiency of computat...
The goal of this work was to develop and evaluate a fast inverse direct aperture optimization (FIDAO) algorithm for IMRT treatment planning and plan adaptation.
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Intensity-Modulated Proton Therapy (IMPT) is known to be sensitive to patient setup and range uncertainty issues. Multiple robust optimization methods have been developed to mitigate the impact of the...
This paper investigates the potential of combined proton-photon therapy treatments in radiation oncology, with a special emphasis on fractionation. Several combined modality models, with and without f...
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A pragmatic randomized clinical trial of patients with locally advanced breast cancer randomized to either proton or photon therapy and followed longitudinally for cardiovascular morbidity...
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes [quality of life (QOL), toxicity, and disease control] between parallel cohorts of men with...
There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous syste...
The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma. The ...
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
Phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.
Tomography using single-photon emitting RADIONUCLIDES to create images that are captured in times corresponding to various points in the cardiac cycle.
A complex of enzymes and PROTON PUMPS located on the inner membrane of the MITOCHONDRIA and in bacterial membranes. The protein complex provides energy in the form of an electrochemical gradient, which may be used by either MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES or BACTERIAL PROTON-TRANSLOCATING ATPASES.
Energy that is generated by the transfer of protons or electrons across an energy-transducing membrane and that can be used for chemical, osmotic, or mechanical work. Proton-motive force can be generated by a variety of phenomena including the operation of an electron transport chain, illumination of a PURPLE MEMBRANE, and the hydrolysis of ATP by a proton ATPase. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed, p171)
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...